Pa Januware 6, 1542, Francisco de Montejo adakhazikitsa Mérida, idamangidwa pa anthu aku Mayan T´ho (pamaso pa Ichcaanziho), idalembetsedwa ngati tawuni yomwe ili ndi mabanja 70 aku Spain ndi Amwenye aku Mayan 300. Pa Julayi 13, 1618 adatchedwa "mzinda wabwino kwambiri komanso wokhulupirika" mu satifiketi yomwe idasainidwa ndi Felipe II.
Katolika wake ndi wakale kwambiri ku New Spain, udayamba mu 1561 ndipo udaperekedwa kwa San Ildefonso, woyang'anira mzindawo. Ntchito zina kuyambira nthawi ya atsamunda ndi akachisi a San Juan Bautista, La Mejorada, San Cristóbal ndi tchalitchi cha Santa Ana. Kachisi wa Third Order, yemwe tsopano ndi Kachisi wa Yesu, adakhala anthu aku Franciscans, pomwe adathamangitsa maJesuit ku New Spain m'zaka za zana la 18.
Zomangamanga zomwe ndizodziwika bwino mumzinda ndi: Casa de Montejo, chifukwa cha mawonekedwe ake a Plateresque; Colegio de San Pedro, yomwe idakhazikitsidwa ndi maJesuit ku 1711, pomwe pano ndi mpando wa State University; Chipatala cha Nuestra Señora del Rosario, lero ndi malo owonetsera zakale; Nyumba Yachifumu ya Canton yomangidwa ndi nsangalabwi ndipo tsopano ikukhala ndi Regional Museum of Anthropology; Nyumba Yaboma, yomwe ili ndi mbiri ya chilumba choimiridwa ndi zojambula pakhoma; Plaza de Armas, Paseo Montejo, msika ndi mapaki a Santiago ndi Santa Lucía.
Kuchokera ku Mérida makilomita 80 kumadzulo ndi Celestún, Special Biosphere Reserve, malo omwe pinki ya flamingo imaswana. Kuti mukayendere malowa muyenera chilolezo kuchokera ku Sedesol. Kumpoto kwa Mérida pamsewu waukulu wopita ku Progreso ndi Dzibilchaltún, m'kachisi wake wa Zidole Zisanu ndi ziwiri Amayan amalembetsa mayikidwe a dzuwa.
Progreso ali ndi pier yayitali kwambiri mdziko muno: Tikukulimbikitsani kuti mupite kumtunda wamakilomita ochepa kuti mukadye nsomba ndi nkhono chifukwa amakhala ndi nyengo yabwino kwambiri ku Yucatan; kum'mawa mutha kusangalala ndi magombe opanda phokoso monga San Benito ndi San Bruno.
Motul ndi komwe Felipe Carrillo Puerto adabadwira, amachokera kumpoto chakum'mawa kwa Mérida. Kupitilira kummawa tili ndi Suma, Cansahcab ndi Temax, tikatembenukira kumpoto mupeza Dzilam de Bravo, mudzi wosodza. Pafupi ndi Boca de Dzilam, madzi abwino amatuluka kuchokera pansi pa nyanja kuwonjezera pokhala dera la cenote.
Tipitiliza kum'mawa kwa Mérida pomwe msewu waukulu wa Mérida-Cancún umayambira, ma kilomita 160 a mseu wopita ku Valladolid. Pakati panjira yomwe timadutsa kulowera kumpoto kuti tikachezere Izamal ndi nyumba yake yachifumu ya San Antonio, yomangidwa pachipinda chapansi chisanachitike ku Spain. Atrium yake imadziwika kuti ndi yayikulu kwambiri ku America.
