Tikukupatsani zowerengera za zomera zomwe zimagwiritsidwa ntchito kwambiri ndi mankhwala azitsamba pochiza matenda osiyanasiyana. Dziwani zamankhwala ogwiritsira ntchito ndikuphunzira zambiri za chikhalidwe chakalechi.
Mosiyana ndi zitsamba zochiritsira zapakati ndi kumwera kwa dzikolo, zakumpoto sizidziwika kwenikweni. Kwakukulukulu izi zidachitika chifukwa choti anthu aku Mesoamerica anali ndi zithunzi, ma codices ndi zojambula pakhoma, komanso miyambo yambiri yapakamwa, ndipo pambuyo pake mu Colony, ndi olemba mbiri komanso asayansi monga Motolinia, Sahún, Landa, Nicolás Monardes ndi Francisco Hernández , pakati pa ena. Magulu akumpoto, kumbali inayo, anali osamukasamuka komanso osagwirizana, chifukwa chake sanasiye umboni wa mankhwala awo, omwe mwina sanali opita patsogolo.
Munali munthawi ya New Spain pomwe amishonale achiJesuit, oyamba ndi aku Franciscans ndi a Augustinians, pambuyo pake, komanso ofufuza omwe ndi mbiri yawo, malipoti, maubale ndi nkhani zawo adasiya zidziwitso zofunikira pazomwe adapeza, zomwe adawona ndi zomwe adaphunzira za mbadwa zitsamba.
M'zaka zaposachedwa kwambiri, kafukufuku wofukula za m'mabwinja, zamitundu ndi kafukufuku wanthaka zomwe zachitika m'derali zathandizira kuti pakhale chidziwitso chofunikira kwambiri pazidziwitso za zomera izi. Ndikofunikira kudziwa kuti mankhwala ambiri azomera adadziwika ndikugwiritsidwa ntchito kalekale Spain asanafike. Mwanjira yoti ma botanist aku Europe ndi naturists (achipembedzo komanso akudziko) anali ndi udindo wowalamula, kuwakhazikitsa ndipo koposa zonse, kuwafalitsa.
Mwamwayi, pakati pa amishonale omwe amalalikira m'derali panali akatswiri owona zachilengedwe, ndipo kwa iwo zambiri zomwe zikudziwika masiku ano zokhudzana ndi mankhwala ake ndizoyenera, popeza kuphunzira za mbewu zakumpoto adaziika munjira yosavuta. Chifukwa chake, panali mbewu zothandiza ndi zomera zoopsa; zoyambilira zidagawika chakudya, mankhwala, hallucinogenic komanso kukongoletsa. Pakadali pano, zowonongekazo zidagwiritsidwa ntchito poizoni mivi, kapena madzi amitsinje, mayiwe ndi malo owolokeramo kusaka ndi kuwedza, motsatana.
Gulu la zitsamba zopangidwa ndi maJesuit lidali lophweka: adadzipangira dzina lawo lachi Spanish, adalifotokoza mwachidule, adazindikira malo omwe adakulira ndi gawo lomwe limagwiritsidwa ntchito, komanso momwe amaperekedwera, komaliza, matenda wachiritsidwa. Anthu achipembedzowa adalongosola zambiri za mankhwala azitsamba, adasonkhanitsa zitsamba, adalima minda ya zipatso ndi minda, adasanthula za malo awo, adatola ndikutumiza zitsanzo ku protomedicato ya Mexico City ndi Spain, kuzigawa ngakhale kuzigulitsa. Koma adabweretsanso zomanga kuchokera ku Europe, Asia ndi Africa zomwe zidazolowereka kuderali. Kuchokera pakumera ndikupita kwa mbewu kumeneku pamabwera tsango lachirengedwe lazitsamba lomwe likugwiritsidwa ntchito m'chigawochi, lodziwika bwino.
