Mbiri ya amishonale ku New Spain mwachionekere idayamba pakubwera kwa azungu ku New Spain. Mwachidule, mawu oti mission amatanthauza ntchito yomwe amayenera kuchita ngati gawo lodzipereka kapena ntchito yomwe apatsidwa.
M'malo ambiri aku Mexico, ntchito ya ma friars inali yovuta kwambiri: kutembenukira ku Chikhristu kwa anthu zikwizikwi mwa njira ya katekisimu, mkati mwa pulogalamu yayikulu yomwe idalola kuti zipembedzo za Akhristu zatsopano zifalitse kumadera omwe anali mwachangu kwambiri kuti muchite ntchito yolalikira. Kwa ma friars, gawolo linali lalikulu, losadziwika ndipo nthawi zambiri linali lotsogola komanso lopanda chiyembekezo, kuphatikiza kukana kwamitundu yakomwe yomwe idakana kuwalandira, chiphunzitso chawo komanso omwe adagonjetsa. Pachifukwa ichi kuyenera kuwonjezeredwa zovuta zazikulu zomwe ansembe anali nazo pophunzira chilankhulo cha zigawo zosiyanasiyana zomwe amayenera kugwira ntchito.
Ntchito yayikulu yolalikira idayambitsidwa ndi a Franciscans, otsatiridwa ndi a Dominicans, Augustinians ndi Jesuits. Oyamba anafika m'maiko aku Mexico ku 1524, ndipo mzaka zochepa adakwaniritsa maziko amakachisi ndi nyumba zachifumu, zotsatira zomveka zokhazikitsira mamishoni oyamba pafupifupi dera lonse lapakati ndi madera akumwera chakum'mawa kwa Republic, ngakhale pambuyo pake amayenera kugawana nawo gawo lawo Gawo la ma Dominican, omwe adafika ku New Spain mu 1526, kuyamba ntchito yawo yachipembedzo ku Oaxaca, Guerrero, Chiapas, Michoacán ndi Morelos.
Kumbali yawo, a Augustinians adafika mu 1533 ndipo mishoni zawo zidaphatikizapo zigawo za Mexico, Hidalgo, Guerrero ndi madera ena a Huasteca.
Sosaiti ya Yesu idawonekera kumapeto kwa 1572; Ngakhale kuyambira pachiyambi ntchito zawo zinali zopitilira maphunziro, makamaka ubwana, sananyalanyaze ntchito zautumwi m'malo omwe zimangoyambira kumene ndipo sizinachitike ndi zipembedzo zina. Chifukwa chake adafika mwachangu ku Guanajuato, San Luis Potosí ndi Coahuila, kuti adzafalikire kumpoto mpaka kufika ku Baja California, Sonora, Sinaloa, Chihuahua ndi Durango.
Chakumapeto kwa zaka za zana la khumi ndi chisanu ndi chisanu ndi chiwiri a Franciscans, ndi chilolezo cha Holy See, adakhazikitsa makoleji a atumwi a amishonale a Propaganda de Fide (kapena kufalitsa chikhulupiriro), potero akuyesera kupereka chidwi chatsopano pakulalikira ndikukonzekeretsa amishonale kuti awonjezere kuyesetsa kwawo gawo lonse la New Spain. Chifukwa chake masukulu a Querétaro, Zacatecas, Mexico, Orizaba ndi Pachuca adatsegulidwa, limodzi ndi awiri amtsogolo ku Zapopan ndi Cholula.
Pambuyo pake, atachotsedwa a Jesuit kudera ladziko mu 1767, zidalola kuti a Franciscans alande maziko awo omwe adakhazikitsidwa kumpoto, ndipo adalanda Alta California, kuphatikiza magawo a Coahuila, Nuevo León, Tamaulipas, Texas, New Mexico ndipo mbali ina ya Sierra Gorda yomwe, pamodzi ndi Baja California, adagawana ndi a Dominican.
M'madera ena chizolowezi chimapitilizabe kupitiliza kuyitanira amisili kumaziko omwe omangidwa ndi anthu olimbikira pantchito yawo yayitali komanso yopweteka yolalikira. Ambiri mwa iwo adasowa kuti apite kukachisi ndi nyumba zachifumu zokhazikika, zomwe zidagwiritsidwanso ntchito ngati poyambira kufikira malo atsopano kufalitsa chipembedzo cha Katolika. Enanso adasiyidwa ngati maumboni osayankhula okhudzana ndi zigawenga zamagazi kapena zokumbukira mokhulupirika za geography yopanda tanthauzo yomwe ngakhale chikhulupiriro sichingathetse.
Zomwe owerenga apeza patsamba ili la Mexico sichidziwika mu Routes of Missions ndi mbiri yotsalira, yomwe nthawi zina imalumikizidwa ndi nthano komanso ngwazi. Mupezanso zotsalira za ntchito ya titanic yochitidwa ndi anthu ochepa, omwe cholinga chawo chokha chinali kuphunzitsa chipembedzo chawo kwa ena ambiri omwe samadziwa momwe angaphunzirire; ntchito yomwe ofufuza ndi olemba mbiri aweruza munjira zambiri komanso pakuwona, ngakhale palibe amene angatsutse zolemetsa zazikulu ndi zauzimu zomwe amuna onsewa adazisiya mdziko lomwe limakumbukirabe malingaliro awo abwino.
