Popeza samadziwa kutalika kwa kumpoto kwa dzikolo, Ajezwiti anafika ku Chihuahua. M'zaka za zana la khumi ndi zisanu ndi ziwiri mphambu zisanu ndi ziwiri, boma lomwe lidalipo kale lidakhazikitsidwa kumwera chakumadzulo ndi zomwe zimadziwika kuti dera la Chínipas, pomwe gawo lonselo lidagawika pakati pa Tarahumara kumtunda ndi kutsika.
Kuyesera koyamba kolalikira Chihuahua kudabwera kuchokera pamaulendo opangidwa ndi maJesuit, omwe adakhazikika m'chigawo cha Sinaloa. Yoyamba kumangidwa m'chigawochi ndi yomwe idakhazikitsidwa ndi a Juan Juan Castini mu 1621 ndipo amadziwika kuti mission ya Chínipas.
AJesuit ankagwira ntchito kumapiri pakati pa Amwenye a Tepehuanes, Guazaparas, ndi Tarahumara, pomwe Afranciscans amagwira ntchito m'zigwa ndi zigwa. Mmishonale woyamba wokhazikika m'dera la Chínipas anali Abambo a Jesuit a Julio Pascual, omwe adaphedwa mu 1632 limodzi ndi bambo Manuel Martínez. Pofika 1680, Fray Juan María Salvatierra adalimbikitsa mwamphamvu ntchito yomwe idalumikizidwa mchaka cha 1690 ndi 1730. Pakatikati mwa zaka za zana la 17 utumwi wa Ajesuit m'chigawo cha Chínipas udakhala umodzi mwamadongosolo komanso otsogola.
Kum'mwera kunali Nabogame komwe mutha kuwona nyumba ya tchalitchi, curate ndi mishoni yomwe bambo Miguel Wiytz adamanga mu 1744. Baborigame Satevo ili m'dera lomwelo, lomwe lidapeza mphamvu zatsopano ndi oyang'anira a bambo Luis Martín ndi Tubares, yomwe idakhazikitsidwa mu 1699 ndi bambo Manuel Ordaz ndikutsitsimutsidwa ndi oyang'anira wolemba mbiri Félix Sebastián. Otsatirawa amadziwika kuti anali olemera kwambiri kutchalitchi, nyumba, ng'ombe ndi ziweto. Pakatikati pali mishoni za Cerocahui, Guazapares, Chínipas, Santa Ana komanso kumpoto kwa Babarocos ndi Moris.
Dera la Tarahumara Baja lidalalikidwa koyamba ndi Abambo Juan Fonte, omwe adalowa koyamba mu 1608. Mu 1639, abambo Jerónimo Figueroa adakhazikitsa ntchito ya San Pablo Balleza ndi ya Huejotitán (San Jerónimo), pomwe nthawi yomweyo bambo José Pascual anali akumanga San Felipe. M'chigawo chomwecho cha Tarahumara mulinso La joya, Santa María de las Cuevas ndi San Javier Savetó, ntchito yomaliza yomangidwa mu 1640 ndi a Virgilio Máez.
Ponena za dera la Tarahumara Alta, lomwe limazungulira pakati ndi kumpoto kwa bungweli, ntchito yolalikira idayambitsidwa ndi Abambo Tardá, Guadalajara, Celada, Tarkay ndi Neuman. Mamishoni omwe anaphatikizidwa m'chigawochi anali: Tonachi, Norogachi, Nonoava, Narárachi, Sisoguichi, Carichi, San Borja, Temechí kapena Temeichi, Coyachi kapena Coyachic, Tomochi kapena Tomochic, Tutuaca kapena Tutuata, Papigochi, Santo Tomás, Matachi ndi Tesomachi. Pakati pa zaka za zana la khumi ndi chisanu ndi chiwiri, mishoni ya ChiJesuit ya Chihuahua idakhala bungwe loyendetsedwa bwino kwambiri, kupatula omwe anali ku California.
M'dera la Chihuahuan munalinso ntchito yaumishonale ya a Franciscans. Cholinga cha achipembedzo chinali kumaliza kulumikizana komwe kudalipo kale kumpoto kwa Zacatecas, komwe adakhazikitsa nyumba zamatchalitchi ku Chihuahua ndi Durango. Masisitere, monga maJesuit, amayenera kukwaniritsa cholinga cholalikira osakhulupirira. Nyumbazi zidapangidwa ndi za Dona Wathu waku Kumpoto, komwe tsopano ndi Ciudad Juárez, San Buenaventura de Atotonilco (Villa López), Santiago Babonoyaba, Parral, Santa Isabel de Tarahumara, San Pedro de los Conchos, Bachiniva kapena Bacínava (Our Lady of Nativity ), Namiquipa (San Pedro Alcántara), Carretas (Santa María de Gracia), Julimes, San Andrés, Nombre de Dios, San Felipe el Real de Chihuahua ndi Casas Grandes.
